Pet food, baby food contamination linked

The research identified the principal contaminants as melamine and cyanuric
acid. Neither of these compounds is very toxic when administered alone; however,
in combination, they form a virtually insoluble complex.

This complex
causes tubular blockade in the kidney, obstructing urine flow and causing renal
failure. The research was done on rats, but because the toxicity depends only on
the two compounds being present in the kidney at the same time, is relevant to
other species, including humans, according to a press release of Oxford
University.

The research also showed that the melamine-cyanuric acid
complex is soluble in acid, suggesting that acidification of the urine in the
distal tubules of the kidney may be a reasonable treatment option.

These
findings are scheduled for publication in the November issue of Toxicological
Sciences.

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