The AFBI disease surveillance laboratories at Stormont and Omagh (Northern Ireland) saw peak numbers of cases of chronic copper poisoning in sheep during the summer of 2015.
While copper is an essential part of enzymes governing many biological functions, sheep are particularly susceptible to the toxic effects of excess copper.
Photo: Emmy Koeleman, RBI
Toxicity is most frequently observed in the Charollais, Texel and Suffolk breeds, and less frequently observed in the mountain breeds. Clinical disease follows a period of excess intake and occurs when the liver’s capacity to store excess copper is exceeded and there is a sudden release of copper by the liver. This typically occurs after weeks or months of accumulation of copper and often coincides with a period of stress on the animal. The sudden release of copper by the liver causes haemolysis and irreversible damage to the kidney and the brain. Copper poisoning is slow to develop but sudden in onset.
Symptoms of copper poisoning
The eyes and skin become jaundiced and post mortem examination reveals an orange liver, black kidneys and red/brown urine. Biochemistry results show a toxic level of copper in the liver and the kidney. Serum copper levels do not provide a reliable warning of imminent toxicity. While blood tests for liver enzymes can assess how much damage has occurred to the liver these tests are not specific for copper toxicity and liver damage can be due to other conditions such as the presence of parasites.
Jaundice of the sclera and conjunctiva in a sheep with chronic copper poisoning. Photo: AFBI
How do sheep consume excess copper?
Feeding concentrates containing high levels of copper, excessive administration of copper containing mineral supplements or boluses, and grazing pastures which have been dressed in pig slurry are typical scenarios in which cases of copper toxicity in sheep may develop. However even a diet with an acceptable copper concentration can also cause subclinical toxicity if fed for long enough to vulnerable breeds. This is because copper is a cumulative poison with the combination of daily exposure and prolonged feeding playing a part.
Every opportunity to reduce the concentrate intake between lactations should be taken. Particular care should be taken with rams as they are usually fed concentrates more regularly and for more prolonged periods. The best way of managing this condition is to minimise long term concentrate use in the diet.
Treatment options exist but they are only effective in the early stages of the clinical disease and are not always effective. AFBI advised to contact the local vet for advice if a farmer is concerned about copper poisoning in the herd.
The Agri-Food & Biosciences Institute (AFBI) was created on 1st April 2006 as an amalgamation of the Department of Agriculture and Rural Development (DARD) Science Service and the Agricultural Research Institute of Northern Ireland (ARINI).
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